Acetone → Phthalazin-1-ylhydrazine;propan-2-ylidenehydrazine

HRID 2415681Notes

Reaction equation

HRID 2415681 reaction equation
Cl.[NH:2]([C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[N:6][N:5]=1)[NH2:3].[CH3:14]C(C)=O>>[CH3:14][C:7](=[N:6][NH2:5])[CH3:8].[NH:2]([C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[N:6][N:5]=1)[NH2:3]

Participants

3

Reactant 2

HCID 180AcetoneHCID 9351Hydralazine Hydrochloride

Product 1

HCID 86590016Phthalazin-1-ylhydrazine;propan-2-ylidenehydrazine

Procedure

1-hydrazinophthalazine HCL (395 mg; 2 mmoles) is dissolved in 2.5 ml of acetone and allowed to react for 1 hour. The solvent is evaporated and the slightly yellow material is dried in vacuo to yield 411 mg of 1-hydrazinophthalazine acetone hydrazone. (99% of theoretical yield). [British Journal of Pharmacology 61: 345-349 (1977)].

Workup

  1. customto react for 1 hour
  2. customThe solvent is evaporated
  3. customthe slightly yellow material is dried in vacuo

Sources & evidence

ORD record
ord-275106abc2654a21b4e70ecff7aa7528
Source dataset
uspto-grants-2004_11
Patent number
US06821974B2

Reaction notes

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