Triethylamine → HCID 25196490, compound

Participants

Reaction Steps

To a solution of tert-butyl [(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(4,6-dihydropyrrolo[3,4-c]pyrazol-5(1H)-yl)-1-methyl-6-oxopiperidin-3-yl]carbamate (70 mg, 0.161 mmol) in dichloromethane (4 mL) at room temperature, triethylamine (0.068 mL, 0.484 mmol) and cyclopropanesulfonyl chloride (0.037 mL, 0.363 mmol) were added. The mixture was stirred for 4 days at room temperature. The residue was purified by preparative TLC on silica gel, eluting with CH2Cl2/MeOH/aqueous NH3 (95/4/1) to give first eluting isomer as isomer A and second eluting isomer as isomer B. Isomer A was treated with TFA/CH2Cl2=1:1 for 1 h to give the title compound. LC-MS: 437.89 (M+1).

Provenance & Evidence