HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 2-Methylsulfanyl-pyrimidine-4-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 2-(Methylsulfanyl)pyrimidine-4-carboxylic acid | HCID 295775 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Methylsulfanyl-pyrimidine-4-carbonyl chloride | HCID 11542901 | 95% |
Reaction Steps
To a solution of 2-methylsulfanyl-pyrimidine-4-carboxylic acid (20 g, 117.7 mmol) in CH2Cl2 (100 mL) is added oxalyl chloride (17.2 g, 197 mmol) and DMF (20 drops). The reaction solution is stirred at room temperature for 18 hours after which the solvent is removed in vacuo to afford 21.2 g, (95% yield) of the desired product as a dark green solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06821971B2 |
| Source dataset | uspto-grants-2004_11 |
| ORD ID | ord-c25c2e660a564fbe91d9203fcae3d808 |
| Source note | uspto-grants-2004_11 |