Benzoyl chloride, 3,4,5-trimethoxy- → HCID 9957740, compound

HRID 2415708Notes

Reaction equation

HRID 2415708 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([O:14][CH3:15])[C:11]=1[O:12][CH3:13])[C:6](Cl)=[O:7].[NH2:16][C:17]1[CH:18]=[C:19]([CH:32]=[CH:33][C:34]=1[CH3:35])[C:20]([NH:22][CH2:23][C:24]1[CH:29]=[CH:28][C:27]([Cl:30])=[C:26]([Cl:31])[CH:25]=1)=[O:21]>>[Cl:31][C:26]1[CH:25]=[C:24]([CH:29]=[CH:28][C:27]=1[Cl:30])[CH2:23][NH:22][C:20](=[O:21])[C:19]1[CH:32]=[CH:33][C:34]([CH3:35])=[C:17]([NH:16][C:6](=[O:7])[C:5]2[CH:4]=[C:3]([O:2][CH3:1])[C:11]([O:12][CH3:13])=[C:10]([O:14][CH3:15])[CH:9]=2)[CH:18]=1

Participants

3

Reactant 2

HCID 78282Benzoyl chloride, 3,4,5-trimethoxy-HCID 22636160HCID 22636160, compound

Product 1

HCID 9957740HCID 9957740, compound

Procedure

Using an analogous procedure to that described in Example 2, 3,4,5-trimethoxybenzoyl chloride was reacted with 3-amino-N-(3,4-dichlorobenzyl)-4-methylbenzamide to give the title compound which was purified by column chromatography using increasingly polar mixtures of methylene chloride and methanol as eluent; NMR Spectrum: (CDCl3) 2.28 (s, 3H), 3.87 (m, 9H), 4.48 (d, 2H), 7.13 (m, 5H), 7.36 (m, 2H), 7.52 (d, 1H), 8.01 (s, 1H), 8.13 (s, 1H); Mass Spectrum: M-H− 503.

Sources & evidence

ORD record
ord-ecf0c743023c47798a1d3e19f8290c4d
Source dataset
uspto-grants-2004_11
Patent number
US06821965B1

Reaction notes

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