1,3-Benzenediamine, N1,N1-dimethyl-, hydrochloride (1:2) → 4-chloro-N-(3-dimethylaminophenyl)-3-(6-quinolylcarbonylamino)benzamide

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Reaction Steps

Using an analogous procedure to that described in Example 1, 4-chloro-3-(6-quinolylcarbonylamino)benzoyl chloride was reacted with 3-dimethylaminoaniline dihydrochloride to give the title compound; NMR Spectrum: (DMSOd6) 3.04 (s, 6H), 6.5 (d, 1H), 7.08-7.20 (m, 3H), 7.61-7.64 (m, 1H), 7.74 (d, 1H), 7.92 (d, 1H) 8.1-8.2 (m, 2H), 7.31 (d, 1H), 8.58 (d, 1H), 8.72 (s, 1H), 9.02 (s, 1H) 10.13 (s, 1H), 10.5 (s, 1H); Mass Spectrum: Mass Spectrum: M+H+ 445 and 447.

Provenance & Evidence