Morpholine → HCID 15563980, compound

HRID 2415764Notes

Reaction equation

HRID 2415764 reaction equation
[C:1]([C:3]1[C:4](Cl)=[N:5][CH:6]=[CH:7][N:8]=1)#[N:2].[NH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1>CO>[N:10]1([C:4]2[C:3]([C:1]#[N:2])=[N:8][CH:7]=[CH:6][N:5]=2)[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 2924653-Chloropyrazine-2-carbonitrile

Product 1

HCID 15563980HCID 15563980, compoundYield 99.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 3-cyano-2-chloropyrazine (0.7 g, 5.0 mmol) in methanol (20 mL) was added morpholine (1.0 mL, 11.0 mmol) and the reaction was stirred at room temperature overnight. The solvent was removed in vacuo, then the residue was dissolved in diethyl ether. The precipitate was filtered off and the filtrate was concentrated under reduce pressure to give the title compound as an orange solid (0.95 g).

Workup

  1. customThe solvent was removed in vacuo
  2. dissolutionthe residue was dissolved in diethyl ether
  3. filtrationThe precipitate was filtered off
  4. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-97f363854b52429180dc43d4186b72e4
Source dataset
uspto-grants-2004_11
Patent number
US06821972B2

Reaction notes

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