反应详情

5 ml of concentrated sulfuric acid is drop-added slowly to 100 ml of methanol. The solution is cooled and then added with a powder of 4-chloro-salicylic acid (17.20 g, 0.1 mol), and a reaction is carried out at reflux for 24 hours. After cooling the reaction, a large amount of deposit precipitates and is filtered out, washed with small amount of methanol, and recrystallized in anhydrous ethanol, to obtain 15.60 g of methyl 4-chloro-salicylate, with a yield of 83%.

1. temperatureThe solution is cooled
2. temperatureat reflux for 24 hours
3. temperatureAfter cooling
4. customthe reaction
5. customa large amount of deposit precipitates
6. filtrationis filtered out
7. washwashed with small amount of methanol
8. customrecrystallized in anhydrous ethanol