HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 86590028, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | HCID 22636752 | HCID 22636752 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 86590028 | HCID 86590028 | 75.2% |
Reaction Steps
{2-[(5-Chloro-1H-indole-2-carbonyl)-amino]-7,8-dihydro-6H-5-oxa-9-aza-benzocyclohepten-9-yl}-acetic acid (80 mg) and pyrrolidine (14.2 mg) were dissolved in anhydrous THF. To that solution was added BOP and the resulting mixture treated with triethylamine (40.5 mg). The reaction was stirred overnight at room temperature. The reaction was evaportated and the crude product purified by TLC using EtOAc as solvent to yield 68 mg of the product. LCMS: AP+ 453/455.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06821977B2 |
| Source dataset | uspto-grants-2004_11 |
| ORD ID | ord-4136d8e90f1a48818ff3eb423c353026 |
| Source note | uspto-grants-2004_11 |