Methyl 2-hydroxy-3-nitrobenzoate → Methyl 3-amino-2-hydroxybenzoate

Participants

Reaction Steps

Methyl-3-nitrosalicylat (4.93 grams, 25 mmol) dissolved in 50 mL of methanol was placed in a Parr bottle together with 200 mg of 10% Pd/C and hydrogenated at room temperature at 45 psi for 2 hours. The reaction was then filtered through celite, concentrated to dryness and the product dried in vacuo. Yield 4.17 gram (99% light green needles, M+168, single spot on TLC.

Provenance & Evidence