反应详情

2,4-difluorophenyl-(4-piperidinyl)-methanone oxime hydrochloride (5.52 g, 20 mmol) is added to 25 ml of 50% potassium hydroxide; reflux for 4 hours, cooled to room temperature, and extracted with toluene (25 ml×2). The combined organic phases are dried over anhydrous magnesium sulfate, filtered, evaporated to dryness under reduced pressure, and recrystallized in diethyl ether, to obtain 3.3 g of a product, with a yield of 75%.

1. temperaturereflux for 4 hours
2. extractionextracted with toluene (25 ml×2)
3. dry with materialThe combined organic phases are dried over anhydrous magnesium sulfate
4. filtrationfiltered
5. customevaporated to dryness under reduced pressure
6. customrecrystallized in diethyl ether