Quipazine → 9-[4-(4-Quinolin-2-yl-piperazin-1-yl)-butyl]-9h-fluorene-9-carboxylic acid-(propyl)-amide

HRID 2415852Notes

Reaction equation

HRID 2415852 reaction equation
[CH2:1]([NH:4][C:5]([C:7]1([CH2:20][CH2:21][CH2:22][CH2:23]Br)[C:19]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2)=[O:6])[CH2:2][CH3:3].[N:25]1([C:31]2[CH:40]=[CH:39][C:38]3[C:33](=[CH:34][CH:35]=[CH:36][CH:37]=3)[N:32]=2)[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>>[CH2:1]([NH:4][C:5]([C:7]1([CH2:20][CH2:21][CH2:22][CH2:23][N:28]2[CH2:29][CH2:30][N:25]([C:31]3[CH:40]=[CH:39][C:38]4[C:33](=[CH:34][CH:35]=[CH:36][CH:37]=4)[N:32]=3)[CH2:26][CH2:27]2)[C:19]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2)=[O:6])[CH2:2][CH3:3]

Participants

3

Reactant 2

HCID 5011QuipazineHCID 226361699-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-propylamide

Product 1

HCID 155523359-[4-(4-Quinolin-2-yl-piperazin-1-yl)-butyl]-9h-fluorene-9-carboxylic acid-(propyl)-amide

Procedure

Prepared analogously to Example 2b from 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-(propyl)-amide and 2-(piperazin-1-yl)-quinoline.

Sources & evidence

ORD record
ord-55c68dec88cf488698d3e50131c30ed8
Source dataset
uspto-grants-2004_11
Patent number
US06821967B2

Reaction notes

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