Quipazine → 9-[4-(4-Quinolin-2-yl-piperazin-1-yl)-butyl]-9h-fluorene-9-carboxylic acid-(ethyl)-amide

HRID 2415856Notes

Reaction equation

HRID 2415856 reaction equation
[CH2:1]([NH:3][C:4]([C:6]1([CH2:19][CH2:20][CH2:21][CH2:22]Br)[C:18]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[C:12]2[C:7]1=[CH:8][CH:9]=[CH:10][CH:11]=2)=[O:5])[CH3:2].[N:24]1([C:30]2[CH:39]=[CH:38][C:37]3[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=3)[N:31]=2)[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1>>[CH2:1]([NH:3][C:4]([C:6]1([CH2:19][CH2:20][CH2:21][CH2:22][N:27]2[CH2:28][CH2:29][N:24]([C:30]3[CH:39]=[CH:38][C:37]4[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=4)[N:31]=3)[CH2:25][CH2:26]2)[C:18]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[C:12]2[C:7]1=[CH:8][CH:9]=[CH:10][CH:11]=2)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 5011QuipazineHCID 22180514HCID 22180514, compound

Product 1

HCID 226362449-[4-(4-Quinolin-2-yl-piperazin-1-yl)-butyl]-9h-fluorene-9-carboxylic acid-(ethyl)-amide

Procedure

Prepared analogously to Example 2b from 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-(ethyl)-amide and 2-(piperazin-1-yl)-quinoline.

Sources & evidence

ORD record
ord-5a0fdea479bf4354bdaf5a6e2fbb2f67
Source dataset
uspto-grants-2004_11
Patent number
US06821967B2

Reaction notes

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