Quipazine → 9-[4-(4-quinolin-2-yl-piperazin-1-yl)-butyl]-9H-fluorene-9-carboxylic acid-(cyclopentyl)-amide

HRID 2415858Notes

Reaction equation

HRID 2415858 reaction equation
[CH:1]1([NH:6][C:7]([C:9]2([CH2:22][CH2:23][CH2:24][CH2:25]Br)[C:21]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[C:15]3[C:10]2=[CH:11][CH:12]=[CH:13][CH:14]=3)=[O:8])[CH2:5][CH2:4][CH2:3][CH2:2]1.[N:27]1([C:33]2[CH:42]=[CH:41][C:40]3[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=3)[N:34]=2)[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>>[CH:1]1([NH:6][C:7]([C:9]2([CH2:22][CH2:23][CH2:24][CH2:25][N:30]3[CH2:31][CH2:32][N:27]([C:33]4[CH:42]=[CH:41][C:40]5[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=5)[N:34]=4)[CH2:28][CH2:29]3)[C:21]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[C:15]3[C:10]2=[CH:11][CH:12]=[CH:13][CH:14]=3)=[O:8])[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 5011QuipazineHCID 226363019-(4-Bromo-butyl)-9h-fluorene-9-carboxylic acid-cyclopentylamide

Product 1

HCID 155523379-[4-(4-quinolin-2-yl-piperazin-1-yl)-butyl]-9H-fluorene-9-carboxylic acid-(cyclopentyl)-amide

Procedure

Prepared analogously to Example 2b from 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-(cyclopentyl)-amide and 2-(piperazin-1-yl)-quinoline.

Sources & evidence

ORD record
ord-6e8af0314f144229b9b14a6cf90ba45e
Source dataset
uspto-grants-2004_11
Patent number
US06821967B2

Reaction notes

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