HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 131724650, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | 2-Chloro-3-methyl-3H-imidazo[4,5-b]pyridine | HCID 10820986 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 131724650 | HCID 131724650 | — |
Reaction Steps
A solution of 3.83 g (0.011 mol)-2-chloro-3-methyl-3H-imidazo[4,5]pyridine, 2.2 g (0.012 mol) of 1-Boc-piperazine and 5 ml (0.029 mol) of ethyl-diisopropylamine in 15 ml of DMSO is stirred for 12 hours at 130° C. Water is added and the mixture is extracted with ethyl acetate. The combined organic phases are dried over sodium sulphate. The product is purified by column chromatography on silica gel (eluant: dichloromethane/acetone=20:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06821967B2 |
| Source dataset | uspto-grants-2004_11 |
| ORD ID | ord-a0010df3cc04464b89d4e029edaab75d |
| Source note | uspto-grants-2004_11 |