tert-Butyl piperazine-1-carboxylate → 9-[4-(4-tert.butyloxycarbonyl-piperazino)-butyl]-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoroethyl)amide

HRID 2415876Notes

Reaction equation

HRID 2415876 reaction equation
[F:1][C:2]([F:26])([F:25])[CH2:3][NH:4][C:5]([C:7]1([CH2:20][CH2:21][CH2:22][CH2:23]Br)[C:19]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2)=[O:6].[C:27]([N:34]1[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]1)([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28]>>[F:1][C:2]([F:26])([F:25])[CH2:3][NH:4][C:5]([C:7]1([CH2:20][CH2:21][CH2:22][CH2:23][N:37]2[CH2:36][CH2:35][N:34]([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH2:39][CH2:38]2)[C:19]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2)=[O:6]

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 105264379-(4-Bromobutyl)-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide

Product 1

HCID 698919759-[4-(4-tert.butyloxycarbonyl-piperazino)-butyl]-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoroethyl)amide

Procedure

Prepared analogously to Example 2 from 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoro-ethyl)-amide and Boc-piperazine.

Sources & evidence

ORD record
ord-dfd60b45563e44459d16c3a00d05e129
Source dataset
uspto-grants-2004_11
Patent number
US06821967B2

Reaction notes

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