Trifluoroacetic acid → 9-(4-piperazino-butyl)-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoro-ethyl)-amide

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Reaction Steps

A solution of 2.3 g (4.32 mmol) of tert. butyl 4-{4-[9-(2,2,2-trifluoro-ethylcarbamoyl)-9H-fluoren-9-yl]-butyl}-piperazine-1-carboxylate and 6 ml of trifluoroacetic acid in 50 ml of dichloromethane is stirred for 14 hours at ambient temperature. Dilute sodium hydroxide solution is added cautiously, so that the solution has a pH of 9. The precipitate formed is filtered off, washed with water and dried.

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