反应详情

6 g (22.21 mmol) of N-(2-bromo-phenyl)-3-ethoxy-acrylamide are added batchwise to 30 ml of concentrated sulphuric acid (exothermic) and stirred for one hour. The reaction mixture is poured onto ice water and the precipitate formed is filtered off. The product is purified by column chromatography on silica gel (eluant: dichloromethane/ethyl acetate=3:1).

1. additionThe reaction mixture is poured onto ice water
2. customthe precipitate formed
3. filtrationis filtered off
4. customThe product is purified by column chromatography on silica gel (eluant: dichloromethane/ethyl acetate=3:1)