HCID 22636365, compound → HCID 22636200, compound

HRID 2415899Notes

Reaction equation

HRID 2415899 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:23]=[CH:22][C:21]3[C:16](=[C:17]([O:24][CH2:25][CH3:26])[CH:18]=[CH:19][CH:20]=3)[CH:15]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>C(O)C.[Pd]>[CH2:25]([O:24][C:17]1[CH:18]=[CH:19][CH:20]=[C:21]2[C:16]=1[CH:15]=[C:14]([N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)[CH:23]=[CH:22]2)[CH3:26]

Participants

5

Reactant 2

HCID 22636365HCID 22636365, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 22636200HCID 22636200, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 24.9 g (0.072 mol) of 1-benzyl-4-(8-ethoxy-naphthalen-2-yl)-piperazine in 360 ml of ethanol is combined with 5 g of palladium on charcoal (10%) and stirred at a hydrogen pressure of 5 bar at ambient temperature. The catalyst is separated off, the filtrate is concentrated by evaporation and the residue is washed with diethylether.

Workup

  1. customThe catalyst is separated off
  2. concentrationthe filtrate is concentrated by evaporation
  3. washthe residue is washed with diethylether

Sources & evidence

ORD record
ord-5e439d2b75a747a889c7031aec7da5f9
Source dataset
uspto-grants-2004_11
Patent number
US06821967B2

Reaction notes

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