HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloroquinoline → HCID 44220319, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloroquinoline | HCID 11928 | — |
| Reactant | 2-Methylpiperazine, (S)- | HCID 2734219 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | HCID 44220319 | HCID 44220319 | — |
Reaction Steps
A solution of 1.554 g (9.5 mmol) of 2-chloroquinoline and 1 g (9.984 mmol) of (S)-2-methylpiperazine in 10 ml of n-butanol is stirred for three hours at 130° C. Then the solvent is distilled off. The residue is purified by column chromatography on silica gel (eluant: dichloromethane/ethanol/ammonia=20:1:0.1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06821967B2 |
| Source dataset | uspto-grants-2004_11 |
| ORD ID | ord-e746fdab2adf4242beccfba061e34c06 |
| Source note | uspto-grants-2004_11 |