2-Chloroquinoline → 2-(cis-3,5-Dimethyl-piperazin-1-yl)-quinoline

HRID 2415908Notes

Reaction equation

HRID 2415908 reaction equation
[CH3:1][C@H:2]1[CH2:7][NH:6][CH2:5][C@@H:4]([CH3:8])[NH:3]1.Cl[C:10]1[CH:19]=[CH:18][C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=1>>[CH3:8][C@H:4]1[NH:3][C@@H:2]([CH3:1])[CH2:7][N:6]([C:10]2[CH:19]=[CH:18][C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=2)[CH2:5]1

Participants

3

Reactant 2

HCID 119282-ChloroquinolineHCID 6950261rel-(2R,6S)-2,6-dimethylpiperazine

Product 1

HCID 698931002-(cis-3,5-Dimethyl-piperazin-1-yl)-quinoline

Procedure

Prepared analogously to Example 38 from cis-2,6-dimethyl-piperazine and 2-chloroquinoline.

Sources & evidence

ORD record
ord-afaa236a0f51448cb0e8b981f4c0884f
Source dataset
uspto-grants-2004_11
Patent number
US06821967B2

Reaction notes

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