5-Chloro-2-piperazin-1-yl-quinoline → 9-{4-[4-(5-chloro-quinolin-2-yl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic Acid-4-fluoro-benzylamide

HRID 2415923Notes

Reaction equation

HRID 2415923 reaction equation
[F:1][C:2]1[CH:29]=[CH:28][C:5]([CH2:6][NH:7][C:8]([C:10]2([CH2:23][CH2:24][CH2:25][CH2:26]Br)[C:22]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[C:16]3[C:11]2=[CH:12][CH:13]=[CH:14][CH:15]=3)=[O:9])=[CH:4][CH:3]=1.[Cl:30][C:31]1[CH:40]=[CH:39][CH:38]=[C:37]2[C:32]=1[CH:33]=[CH:34][C:35]([N:41]1[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]1)=[N:36]2>>[F:1][C:2]1[CH:29]=[CH:28][C:5]([CH2:6][NH:7][C:8]([C:10]2([CH2:23][CH2:24][CH2:25][CH2:26][N:44]3[CH2:45][CH2:46][N:41]([C:35]4[CH:34]=[CH:33][C:32]5[C:37](=[CH:38][CH:39]=[CH:40][C:31]=5[Cl:30])[N:36]=4)[CH2:42][CH2:43]3)[C:22]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[C:16]3[C:11]2=[CH:12][CH:13]=[CH:14][CH:15]=3)=[O:9])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 216804175-Chloro-2-piperazin-1-yl-quinolineHCID 226362389-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-4-fluoro-benzylamide

Product 1

HCID 226362019-{4-[4-(5-chloro-quinolin-2-yl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic Acid-4-fluoro-benzylamide

Procedure

Prepared analogously to Example 2 from 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-4-fluoro-benzylamide and 5-chloro-2-piperazin-1-yl-quinoline.

Sources & evidence

ORD record
ord-9bb3dd7232cb478ab1791417015fd002
Source dataset
uspto-grants-2004_11
Patent number
US06821967B2

Reaction notes

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