9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-4-fluoro-benzylamide → HCID 22636338, compound

HRID 2415930Notes

Reaction equation

HRID 2415930 reaction equation
[F:1][C:2]1[CH:29]=[CH:28][C:5]([CH2:6][NH:7][C:8]([C:10]2([CH2:23][CH2:24][CH2:25][CH2:26]Br)[C:22]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[C:16]3[C:11]2=[CH:12][CH:13]=[CH:14][CH:15]=3)=[O:9])=[CH:4][CH:3]=1.[F:30][C:31]1[CH:32]=[CH:33][C:34]2[N:38]=[C:37]([N:39]3[CH2:44][CH2:43][NH:42][CH2:41][CH2:40]3)[N:36]([CH3:45])[C:35]=2[CH:46]=1>>[F:1][C:2]1[CH:29]=[CH:28][C:5]([CH2:6][NH:7][C:8]([C:10]2([CH2:23][CH2:24][CH2:25][CH2:26][N:42]3[CH2:43][CH2:44][N:39]([C:37]4[N:36]([CH3:45])[C:35]5[CH:46]=[C:31]([F:30])[CH:32]=[CH:33][C:34]=5[N:38]=4)[CH2:40][CH2:41]3)[C:22]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[C:16]3[C:11]2=[CH:12][CH:13]=[CH:14][CH:15]=3)=[O:9])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 226362389-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-4-fluoro-benzylamideHCID 22636364HCID 22636364, compound

Product 1

HCID 22636338HCID 22636338, compound

Procedure

Prepared analogously to Example 1e from 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-4-fluoro-benzylamide and 6-fluoro-1-methyl-2-piperazin-1-yl-1H-benzimidazole.

Sources & evidence

ORD record
ord-ab89b3eaee824b13ae4f1e785cb6df46
Source dataset
uspto-grants-2004_11
Patent number
US06821967B2

Reaction notes

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