2-(1,4-Diazepan-1-yl)benzo[d]thiazole → 9-[4-(4-benzothiazol-2-yl-[1.4]diazepan-1-yl)-butyl]-9H-fluorene-9-carboxylic Acid-4-fluoro-benzylamide

HRID 2415938Notes

Reaction equation

HRID 2415938 reaction equation
[F:1][C:2]1[CH:29]=[CH:28][C:5]([CH2:6][NH:7][C:8]([C:10]2([CH2:23][CH2:24][CH2:25][CH2:26]Br)[C:22]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[C:16]3[C:11]2=[CH:12][CH:13]=[CH:14][CH:15]=3)=[O:9])=[CH:4][CH:3]=1.[N:30]1([C:37]2[S:38][C:39]3[CH:45]=[CH:44][CH:43]=[CH:42][C:40]=3[N:41]=2)[CH2:36][CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1>>[F:1][C:2]1[CH:29]=[CH:28][C:5]([CH2:6][NH:7][C:8]([C:10]2([CH2:23][CH2:24][CH2:25][CH2:26][N:33]3[CH2:34][CH2:35][CH2:36][N:30]([C:37]4[S:38][C:39]5[CH:45]=[CH:44][CH:43]=[CH:42][C:40]=5[N:41]=4)[CH2:31][CH2:32]3)[C:22]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[C:16]3[C:11]2=[CH:12][CH:13]=[CH:14][CH:15]=3)=[O:9])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 167851792-(1,4-Diazepan-1-yl)benzo[d]thiazoleHCID 226362389-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-4-fluoro-benzylamide

Product 1

HCID 226362979-[4-(4-benzothiazol-2-yl-[1.4]diazepan-1-yl)-butyl]-9H-fluorene-9-carboxylic Acid-4-fluoro-benzylamide

Procedure

Prepared analogously to Example 1 from 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-4-fluoro-benzylamide and 2-[1.4]diazepan-1-yl-benzothiazole.

Sources & evidence

ORD record
ord-907fd457b64a4b73a9c93fd6ccf003d7
Source dataset
uspto-grants-2004_11
Patent number
US06821967B2

Reaction notes

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