Quipazine → 9-[4-(4-quinolin-2-yl-piperazin-1-yl)-butyl]-9H-fluorene-9-carboxylic acid-4-methoxy-benzylamide

HRID 2415940Notes

Reaction equation

HRID 2415940 reaction equation
[CH3:1][O:2][C:3]1[CH:30]=[CH:29][C:6]([CH2:7][NH:8][C:9]([C:11]2([CH2:24][CH2:25][CH2:26][CH2:27]Br)[C:23]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[C:17]3[C:12]2=[CH:13][CH:14]=[CH:15][CH:16]=3)=[O:10])=[CH:5][CH:4]=1.[N:31]1([C:37]2[CH:46]=[CH:45][C:44]3[C:39](=[CH:40][CH:41]=[CH:42][CH:43]=3)[N:38]=2)[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1>>[CH3:1][O:2][C:3]1[CH:30]=[CH:29][C:6]([CH2:7][NH:8][C:9]([C:11]2([CH2:24][CH2:25][CH2:26][CH2:27][N:34]3[CH2:35][CH2:36][N:31]([C:37]4[CH:46]=[CH:45][C:44]5[C:39](=[CH:40][CH:41]=[CH:42][CH:43]=5)[N:38]=4)[CH2:32][CH2:33]3)[C:23]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[C:17]3[C:12]2=[CH:13][CH:14]=[CH:15][CH:16]=3)=[O:10])=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 5011QuipazineHCID 226363179-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-4-methoxy-benzylamide

Product 1

HCID 226362489-[4-(4-quinolin-2-yl-piperazin-1-yl)-butyl]-9H-fluorene-9-carboxylic acid-4-methoxy-benzylamide

Procedure

Prepared analogously to Example 2 from 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-4-methoxy-benzylamide and 2-piperazin-1-yl-quinoline.

Sources & evidence

ORD record
ord-daee7eee16cc484eb7b1283273f3cb56
Source dataset
uspto-grants-2004_11
Patent number
US06821967B2

Reaction notes

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