9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-4-methoxy-benzylamide → 9-[4-(cis-2,6-dimethyl-4-quinolin-2-yl-piperazin-1-yl)-butyl]-9H-fluorene-9-carboxylic Acid-4-methoxy-benzylamide

HRID 2415945Notes

Reaction equation

HRID 2415945 reaction equation
[CH3:1][O:2][C:3]1[CH:30]=[CH:29][C:6]([CH2:7][NH:8][C:9]([C:11]2([CH2:24][CH2:25][CH2:26][CH2:27]Br)[C:23]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[C:17]3[C:12]2=[CH:13][CH:14]=[CH:15][CH:16]=3)=[O:10])=[CH:5][CH:4]=1.[CH3:31][C@H:32]1[NH:37][C@@H:36]([CH3:38])[CH2:35][N:34]([C:39]2[CH:48]=[CH:47][C:46]3[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=3)[N:40]=2)[CH2:33]1>>[CH3:1][O:2][C:3]1[CH:30]=[CH:29][C:6]([CH2:7][NH:8][C:9]([C:11]2([CH2:24][CH2:25][CH2:26][CH2:27][N:37]3[C@H:36]([CH3:38])[CH2:35][N:34]([C:39]4[CH:48]=[CH:47][C:46]5[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=5)[N:40]=4)[CH2:33][C@@H:32]3[CH3:31])[C:23]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[C:17]3[C:12]2=[CH:13][CH:14]=[CH:15][CH:16]=3)=[O:10])=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 226363179-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-4-methoxy-benzylamideHCID 698931002-(cis-3,5-Dimethyl-piperazin-1-yl)-quinoline

Product 1

HCID 235268489-[4-(cis-2,6-dimethyl-4-quinolin-2-yl-piperazin-1-yl)-butyl]-9H-fluorene-9-carboxylic Acid-4-methoxy-benzylamide

Procedure

Prepared analogously to Example 1 from 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-4-methoxy-benzylamide and 2-(cis-3,5-dimethyl-piperazin-1-yl)-quinoline

Sources & evidence

ORD record
ord-b2ba1644a8fd4225a0950411a1ffa7b5
Source dataset
uspto-grants-2004_11
Patent number
US06821967B2

Reaction notes

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