2-(1,4-Diazepan-1-yl)benzo[d]thiazole → 9-[4-(4-benzothiazol-2-yl-[1.4]diazepan-1-yl)-butyl]-9H-fluorene-9-carboxylic Acid-4-methoxy-benzylamide

HRID 2415947Notes

Reaction equation

HRID 2415947 reaction equation
[CH3:1][O:2][C:3]1[CH:30]=[CH:29][C:6]([CH2:7][NH:8][C:9]([C:11]2([CH2:24][CH2:25][CH2:26][CH2:27]Br)[C:23]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[C:17]3[C:12]2=[CH:13][CH:14]=[CH:15][CH:16]=3)=[O:10])=[CH:5][CH:4]=1.[N:31]1([C:38]2[S:39][C:40]3[CH:46]=[CH:45][CH:44]=[CH:43][C:41]=3[N:42]=2)[CH2:37][CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1>>[CH3:1][O:2][C:3]1[CH:30]=[CH:29][C:6]([CH2:7][NH:8][C:9]([C:11]2([CH2:24][CH2:25][CH2:26][CH2:27][N:34]3[CH2:35][CH2:36][CH2:37][N:31]([C:38]4[S:39][C:40]5[CH:46]=[CH:45][CH:44]=[CH:43][C:41]=5[N:42]=4)[CH2:32][CH2:33]3)[C:23]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[C:17]3[C:12]2=[CH:13][CH:14]=[CH:15][CH:16]=3)=[O:10])=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 167851792-(1,4-Diazepan-1-yl)benzo[d]thiazoleHCID 226363179-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-4-methoxy-benzylamide

Product 1

HCID 226361689-[4-(4-benzothiazol-2-yl-[1.4]diazepan-1-yl)-butyl]-9H-fluorene-9-carboxylic Acid-4-methoxy-benzylamide

Procedure

Prepared analogously to Example 1 from 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-4-methoxy-benzylamide and 2-[1.4]diazepan-1-yl-benzothiazole.

Sources & evidence

ORD record
ord-b49413bdf6e24ecd8a2e2378212e3af6
Source dataset
uspto-grants-2004_11
Patent number
US06821967B2

Reaction notes

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