3,4-Difluorobenzylamine → 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-3,4-difluoro-benzylamide

HRID 2415957Notes

Reaction equation

HRID 2415957 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[F:10])[CH2:5][NH2:6].[Br:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]1([C:29](Cl)=[O:30])[C:28]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[C:22]2[C:17]1=[CH:18][CH:19]=[CH:20][CH:21]=2>>[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[F:10])[CH2:5][NH:6][C:29]([C:16]1([CH2:15][CH2:14][CH2:13][CH2:12][Br:11])[C:28]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[C:22]2[C:17]1=[CH:18][CH:19]=[CH:20][CH:21]=2)=[O:30]

Participants

3

Reactant 2

HCID 1235723,4-DifluorobenzylamineHCID 105227589-(4-bromo-butyl)-9H-fluorene-9-carboxylic Acid Chloride

Product 1

HCID 226361939-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-3,4-difluoro-benzylamide

Procedure

Prepared analogously to Example 1 from 3,4-difluorobenzylamine and 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid chloride.

Sources & evidence

ORD record
ord-de1a87922dfa4164b7cab2e4fb96069b
Source dataset
uspto-grants-2004_11
Patent number
US06821967B2

Reaction notes

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