Quipazine → 9-[4-(4-quinolin-2-yl-piperazin-1-yl)-butyl]-9H-fluorene-9-carboxylic Acid-(pyridin-4-ylmethyl)-amide

HRID 2415963Notes

Reaction equation

HRID 2415963 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][NH:8][C:9]([C:11]2([CH2:24][CH2:25][CH2:26][CH2:27]Br)[C:23]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[C:17]3[C:12]2=[CH:13][CH:14]=[CH:15][CH:16]=3)=[O:10])=[CH:3][CH:2]=1.[N:29]1([C:35]2[CH:44]=[CH:43][C:42]3[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=3)[N:36]=2)[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1>>[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][NH:8][C:9]([C:11]2([CH2:24][CH2:25][CH2:26][CH2:27][N:32]3[CH2:33][CH2:34][N:29]([C:35]4[CH:44]=[CH:43][C:42]5[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=5)[N:36]=4)[CH2:30][CH2:31]3)[C:23]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[C:17]3[C:12]2=[CH:13][CH:14]=[CH:15][CH:16]=3)=[O:10])=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 5011QuipazineHCID 226361749-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-(pyridin-4-ylmethyl)-amide

Product 1

HCID 226361959-[4-(4-quinolin-2-yl-piperazin-1-yl)-butyl]-9H-fluorene-9-carboxylic Acid-(pyridin-4-ylmethyl)-amide

Procedure

Prepared analogously to Example 2 from 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-(pyridin-4-ylmethyl)-amide and 2-piperazin-1-yl-quinoline.

Sources & evidence

ORD record
ord-e88bcc28ae4e41f9824b9e88ac3e98f0
Source dataset
uspto-grants-2004_11
Patent number
US06821967B2

Reaction notes

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