1-methyl-2-(piperazin-1-yl)-1H-benzo[d]imidazole → 9-{4-[4-(1-methyl-1H-benzimidazol-2-yl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic Acid Propylamide

HRID 2415968Notes

Reaction equation

HRID 2415968 reaction equation
[CH2:1]([NH:4][C:5]([C:7]1([CH2:20][CH2:21][CH2:22][CH2:23]Br)[C:19]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2)=[O:6])[CH2:2][CH3:3].[CH3:25][N:26]1[C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=2[N:28]=[C:27]1[N:35]1[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]1>>[CH2:1]([NH:4][C:5]([C:7]1([CH2:20][CH2:21][CH2:22][CH2:23][N:38]2[CH2:39][CH2:40][N:35]([C:27]3[N:26]([CH3:25])[C:30]4[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=4[N:28]=3)[CH2:36][CH2:37]2)[C:19]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2)=[O:6])[CH2:2][CH3:3]

Participants

3

Reactant 2

HCID 6675511-methyl-2-(piperazin-1-yl)-1H-benzo[d]imidazoleHCID 226361699-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-propylamide

Product 1

HCID 698929969-{4-[4-(1-methyl-1H-benzimidazol-2-yl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic Acid Propylamide

Procedure

Prepared analogously to Example 1 from 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-propylamide and 1-methyl-2-piperazin-1-yl-1H-benzimidazole.

Sources & evidence

ORD record
ord-4b69d3dc370f48c39f330cc54327f92a
Source dataset
uspto-grants-2004_11
Patent number
US06821967B2

Reaction notes

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