Quipazine → 9-[4-(4-quinolin-2-yl-piperazin-1-yl)-butyl]-9H-fluorene-9-carboxylic Acid-(phenethyl)-amide

HRID 2415970Notes

Reaction equation

HRID 2415970 reaction equation
[CH2:1]([NH:9][C:10]([C:12]1([CH2:25][CH2:26][CH2:27][CH2:28]Br)[C:24]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[C:18]2[C:13]1=[CH:14][CH:15]=[CH:16][CH:17]=2)=[O:11])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[N:30]1([C:36]2[CH:45]=[CH:44][C:43]3[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=3)[N:37]=2)[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1>>[CH2:1]([NH:9][C:10]([C:12]1([CH2:25][CH2:26][CH2:27][CH2:28][N:33]2[CH2:34][CH2:35][N:30]([C:36]3[CH:45]=[CH:44][C:43]4[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=4)[N:37]=3)[CH2:31][CH2:32]2)[C:24]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[C:18]2[C:13]1=[CH:14][CH:15]=[CH:16][CH:17]=2)=[O:11])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 5011QuipazineHCID 226362299-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-(phenethyl)-amide

Product 1

HCID 226363479-[4-(4-quinolin-2-yl-piperazin-1-yl)-butyl]-9H-fluorene-9-carboxylic Acid-(phenethyl)-amide

Procedure

Prepared analogously to Example 2 from 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-(phenethyl)-amide and 2-piperazin-1-yl-quinoline.

Sources & evidence

ORD record
ord-73327399c849437e8b2563bf435a815f
Source dataset
uspto-grants-2004_11
Patent number
US06821967B2

Reaction notes

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