Quipazine → 9-[4-(4-quinolin-2-yl-piperazin-1-yl)-butyl]-9H-xanthene-9-carboxylic Acid-(2,2,2-trifluoro-ethyl)-amide

HRID 2415983Notes

Reaction equation

HRID 2415983 reaction equation
[F:1][C:2]([F:27])([F:26])[CH2:3][NH:4][C:5]([C:7]1([CH2:21][CH2:22][CH2:23][CH2:24]Br)[C:20]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[O:14][C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2)=[O:6].[N:28]1([C:34]2[CH:43]=[CH:42][C:41]3[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=3)[N:35]=2)[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[F:1][C:2]([F:27])([F:26])[CH2:3][NH:4][C:5]([C:7]1([CH2:21][CH2:22][CH2:23][CH2:24][N:31]2[CH2:32][CH2:33][N:28]([C:34]3[CH:43]=[CH:42][C:41]4[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=4)[N:35]=3)[CH2:29][CH2:30]2)[C:20]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[O:14][C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2)=[O:6]

Participants

3

Reactant 2

HCID 5011QuipazineHCID 221802034-[9-(2,2,2-Trifluoroethylcarbamoyl)-9H-xanthen-9-yl]butyl bromide

Product 1

HCID 226362989-[4-(4-quinolin-2-yl-piperazin-1-yl)-butyl]-9H-xanthene-9-carboxylic Acid-(2,2,2-trifluoro-ethyl)-amide

Procedure

Prepared analogously to Example 2b from 9-(4-bromo-butyl)-9H-xanthene-9-carboxylic acid-(2,2,2-trifluoro-ethyl)-amide and 2-(piperazin-1-yl)-quinoline.

Sources & evidence

ORD record
ord-6ddbde6df9444c78a188c73017aeed21
Source dataset
uspto-grants-2004_11
Patent number
US06821967B2

Reaction notes

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