4-[9-(2,2,2-Trifluoroethylcarbamoyl)-9H-xanthen-9-yl]butyl bromide → 9-{4-[4-(8-chloro-quinolin-2-yl)-piperazin-1-yl]-butyl}-9H-xanthene-9-carboxylic Acid-(2,2,2-trifluoro-ethyl)-amide

HRID 2415986Notes

Reaction equation

HRID 2415986 reaction equation
[F:1][C:2]([F:27])([F:26])[CH2:3][NH:4][C:5]([C:7]1([CH2:21][CH2:22][CH2:23][CH2:24]Br)[C:20]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[O:14][C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2)=[O:6].[Cl:28][C:29]1[CH:30]=[CH:31][CH:32]=[C:33]2[C:38]=1[N:37]=[C:36]([N:39]1[CH2:44][CH2:43][NH:42][CH2:41][CH2:40]1)[CH:35]=[CH:34]2>>[F:1][C:2]([F:27])([F:26])[CH2:3][NH:4][C:5]([C:7]1([CH2:21][CH2:22][CH2:23][CH2:24][N:42]2[CH2:43][CH2:44][N:39]([C:36]3[CH:35]=[CH:34][C:33]4[C:38](=[C:29]([Cl:28])[CH:30]=[CH:31][CH:32]=4)[N:37]=3)[CH2:40][CH2:41]2)[C:20]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[O:14][C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2)=[O:6]

Participants

3

Reactant 2

HCID 221802034-[9-(2,2,2-Trifluoroethylcarbamoyl)-9H-xanthen-9-yl]butyl bromideHCID 226362878-Chloro-2-piperazin-1-yl-quinoline

Product 1

HCID 226363439-{4-[4-(8-chloro-quinolin-2-yl)-piperazin-1-yl]-butyl}-9H-xanthene-9-carboxylic Acid-(2,2,2-trifluoro-ethyl)-amide

Procedure

Prepared analogously to Example 2 from 9-(4-bromo-butyl)-9H-xanthene-9-carboxylic acid-(2,2,2-trifluoro-ethyl)-amide and 8-chloro-2-piperazin-1-yl-quinoline. Melting point: 68° C. C33H32ClF3N4O2 (M=609.09) Calc.: molecular peak (M+H)+: 609/611. Found: molecular peak (M+H)+: 609/611.

Sources & evidence

ORD record
ord-4fb480de5e8440d4a6d760019f68f64f
Source dataset
uspto-grants-2004_11
Patent number
US06821967B2

Reaction notes

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