2-(1,4-Diazepan-1-yl)benzo[d]thiazole → 9-[4-(4-benzothiazol-2-yl-[1.4]diazepan-1-yl)-butyl]-9H-xanthene-9-carboxylic Acid-(2,2,2-trifluoro-ethyl)-amide

HRID 2415993Notes

Reaction equation

HRID 2415993 reaction equation
[F:1][C:2]([F:27])([F:26])[CH2:3][NH:4][C:5]([C:7]1([CH2:21][CH2:22][CH2:23][CH2:24]Br)[C:20]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[O:14][C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2)=[O:6].[N:28]1([C:35]2[S:36][C:37]3[CH:43]=[CH:42][CH:41]=[CH:40][C:38]=3[N:39]=2)[CH2:34][CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[F:1][C:2]([F:27])([F:26])[CH2:3][NH:4][C:5]([C:7]1([CH2:21][CH2:22][CH2:23][CH2:24][N:31]2[CH2:32][CH2:33][CH2:34][N:28]([C:35]3[S:36][C:37]4[CH:43]=[CH:42][CH:41]=[CH:40][C:38]=4[N:39]=3)[CH2:29][CH2:30]2)[C:20]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[O:14][C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2)=[O:6]

Participants

3

Reactant 2

HCID 167851792-(1,4-Diazepan-1-yl)benzo[d]thiazoleHCID 221802034-[9-(2,2,2-Trifluoroethylcarbamoyl)-9H-xanthen-9-yl]butyl bromide

Product 1

HCID 226363009-[4-(4-benzothiazol-2-yl-[1.4]diazepan-1-yl)-butyl]-9H-xanthene-9-carboxylic Acid-(2,2,2-trifluoro-ethyl)-amide

Procedure

Prepared analogously to Example 1 from 9-(4-bromo-butyl)-9H-xanthene-9-carboxylic acid-(2,2,2-trifluoro-ethyl)-amide and 2-[1.4]diazepan-1-yl-benzothiazole.

Sources & evidence

ORD record
ord-f4c7291e13f14dda8c6cf0f7ad089d88
Source dataset
uspto-grants-2004_11
Patent number
US06821967B2

Reaction notes

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