Quipazine → 1-morpholin-4-yl-1-{9-[4-(4-quinolin-2-yl-piperazin-1-yl)-butyl]-9H-xanthene-9-yl}-methanone

HRID 2416003Notes

Reaction equation

HRID 2416003 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][C:6]1([C:20]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)=[O:21])[C:19]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[O:13][C:12]2[C:7]1=[CH:8][CH:9]=[CH:10][CH:11]=2.[N:28]1([C:34]2[CH:43]=[CH:42][C:41]3[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=3)[N:35]=2)[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[N:22]1([C:20]([C:6]2([CH2:5][CH2:4][CH2:3][CH2:2][N:31]3[CH2:32][CH2:33][N:28]([C:34]4[CH:43]=[CH:42][C:41]5[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=5)[N:35]=4)[CH2:29][CH2:30]3)[C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=3[O:13][C:14]3[C:19]2=[CH:18][CH:17]=[CH:16][CH:15]=3)=[O:21])[CH2:23][CH2:24][O:25][CH2:26][CH2:27]1

Participants

3

Reactant 2

HCID 5011QuipazineHCID 226362271-[9-(4-bromo-butyl)-9H-xanthen-9-yl]-1-morpholin-4-yl-methanone

Product 1

HCID 226363271-morpholin-4-yl-1-{9-[4-(4-quinolin-2-yl-piperazin-1-yl)-butyl]-9H-xanthene-9-yl}-methanone

Procedure

Prepared analogously to Example 1 from 1-[9-(4-bromo-butyl)-9H-xanthen-9-yl]-1-morpholin-4-yl-methanone and 2-piperazin-1-yl-quinoline.

Sources & evidence

ORD record
ord-cce87fd1873844008e780f7f454db93f
Source dataset
uspto-grants-2004_11
Patent number
US06821967B2

Reaction notes

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