Sodium Hydroxide → HCID 178525595, compound

HRID 2416062Notes

Reaction equation

C([O:3][C:4](=[O:43])[CH2:5][CH2:6][NH:7][C:8]1[S:9][C:10](=[CH:14][C:15]2[CH:20]=[CH:19][C:18]([N:21]3[CH2:26][CH2:25][CH:24]([NH:27][CH2:28][C@H:29]([OH:42])[CH2:30][O:31][C:32]4[C:40]5[NH:39][C:38](=[O:41])[NH:37][C:36]=5[CH:35]=[CH:34][CH:33]=4)[CH2:23][CH2:22]3)=[CH:17][CH:16]=2)[C:11](=[O:13])[N:12]=1)C.[OH-].[Na+]>>[OH:42][C@H:29]([CH2:30][O:31][C:32]1[C:40]2[NH:39][C:38](=[O:41])[NH:37][C:36]=2[CH:35]=[CH:34][CH:33]=1)[CH2:28][NH:27][CH:24]1[CH2:23][CH2:22][N:21]([C:18]2[CH:19]=[CH:20][C:15]([CH:14]=[C:10]3[S:9][C:8]([NH:7][CH2:6][CH2:5][C:4]([OH:43])=[O:3])=[N:12][C:11]3=[O:13])=[CH:16][CH:17]=2)[CH2:26][CH2:25]1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 178471974HCID 178471974, compound

Product 1

HCID 178525595HCID 178525595, compound

Procedure

The title compound was prepared from 3-[5-(4-{4-[(2S)-2-hydroxy-3-(2-oxo-2,3-dihydro-1H-benzoimidazol-4-yloxy)-propylamino]-piperidin-1-yl}-benzylidene)-4-oxo-4,5-dihydro-thiazol-2-ylamino]-propionic acid ethyl ester(which was obtained in Example 8)by NaOH hydrolysis as a pale yellowish solid; MS (ES) m/z: 291.0 ((M+2H)2+, 100%); 581.0 (MH+, 30%); HRMS Calcd. for C28H33N6O6S (MH+): 581.2182. Found: 581.2195.

Sources & evidence

ORD record: ord-e2be6d095d27484894539ecba94089c1
Source dataset: uspto-grants-2004_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06821991B2

Reaction notes

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