Sodium Bicarbonate → HCID 22637162, compound

Participants

Reaction Steps

N-[4-(3-Chloro-4-fluoro-phenylamino)-3-cyano-7-ethoxy-6-quinolinyl)-4-bromo-2-butenamide (150 mg, 0.3 mmol) in 0.7 mL of DMF was reacted with (R)-(+)-3-pyrrolidinol (0.2 mL, 2.4 mmol) at room temperature. After reacting for 4 hours, the reaction solution was added into saturated sodium bicarbonate solution. The resulting precipitate was filtered and washed with water and ether consecutively to give 150 mg of the title compound as a light brown solid, mp 139-143° C.; MS (ES) m/z calcd. 583.2236, found 583.2242 (M+1).

Provenance & Evidence