Dimethylamine → HCID 22637164, compound

Participants

Reaction Steps

To a stirred solution of N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-2-butenamide (0.212 g, 0.50 mmol) in 25 ml of 2.0 M dimethylamine in tetrahydrofuran was added 0.02 ml of 40% aqueous Triton B. After 66 h at 25° C. the solution was concentrated, and the residue was partitioned between methylene chloride and water. The residue from the organic layer was dissolved in ether, and the solution was passed onto a pad of hydrous magnesium silicate. The pad was washed with ether and ethyl acetate to give the product as an amber foam after evaporation (0.23 g). Mass spectrum (electrospray, m/e) 469.9 (M+H)+, 235.5 (M+2H)+2.

Provenance & Evidence