HCID 4572530, compound → 2,3-Diphenyl-5-aminoquinoxaline

HRID 2416091Notes

Reaction equation

HRID 2416091 reaction equation
[C:1]1([C:7]2[C:16]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[N:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][C:13]=3[N+:23]([O-])=O)[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>O1CCOCC1>[C:1]1([C:7]2[C:16]([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)=[N:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][C:13]=3[NH2:23])[N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 1

HCID 4572530HCID 4572530, compound

Product 1

HCID 117793842,3-Diphenyl-5-aminoquinoxaline

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

1.04 g of 2,3-diphenyl-5-nitroquinoxaline was dissolved in 30 g of dioxane, then the reaction system was flushed with argon, and 0.5 g of Pd/C (anhydrous) was added to the reaction mixture. After the reaction system was again flushed with argon sufficiently, hydrogen was added thereto, and reaction was allowed at room temperature for 30 hr. After the reaction was over, filtration was conducted, the reaction solvent was removed, and the reaction product was separated and purified on a silica gel column (ethyl acetate:hexane=1:3).

Workup

  1. customthe reaction system was flushed with argon, and 0.5 g of Pd/C (anhydrous)
  2. additionwas added to the reaction mixture
  3. customAfter the reaction system was again flushed with argon sufficiently
  4. additionhydrogen was added
  5. customreaction
  6. filtrationfiltration
  7. customthe reaction solvent was removed
  8. customthe reaction product was separated
  9. custompurified on a silica gel column (ethyl acetate:hexane=1:3)

Sources & evidence

ORD record
ord-afc91a55898b4e54abfb9611ae8d7c9a
Source dataset
uspto-grants-2004_11
Patent number
US06822069B2

Reaction notes

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