HCID 5052632, compound → HCID 22638468, compound

HRID 2416093Notes

Reaction equation

HRID 2416093 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17]([C:18]3[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][CH:19]=3)=[N:16][C:15]3[C:10](=[CH:11][CH:12]=[CH:13][C:14]=3[N+:25]([O-])=O)[N:9]=2)=[CH:4][CH:3]=1>O1CCOCC1>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:17]([C:18]3[CH:19]=[CH:20][C:21]([CH3:24])=[CH:22][CH:23]=3)=[N:16][C:15]3[C:10](=[CH:11][CH:12]=[CH:13][C:14]=3[NH2:25])[N:9]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 5052632HCID 5052632, compound

Product 1

HCID 22638468HCID 22638468, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

2.02 g (0.0057 mol) of 2,3-di(4-methylphenyl)-5-nitroquinoxaline was dissolved in 30 g of dioxane, then the reaction system was flushed with argon, and 0.6 g of PdC (anhydrous) was added thereto. After the reaction system was again flushed with argon, it was flushed with hydrogen, and reaction was allowed at room temperature for 18 hr. After the reaction was over, the reaction mixture was filtered, the filter cake was washed with acetone and dioxane, and filtration was again conducted. The solvent was removed from the filtrate obtained, and the reaction product was extracted on a silica gel column.

Workup

  1. customthe reaction system was flushed with argon, and 0.6 g of PdC (anhydrous)
  2. additionwas added
  3. customAfter the reaction system was again flushed with argon, it
  4. customwas flushed with hydrogen, and reaction
  5. filtrationwas filtered
  6. washthe filter cake was washed with acetone and dioxane, and filtration
  7. customThe solvent was removed from the filtrate
  8. customobtained
  9. extractionthe reaction product was extracted on a silica gel column

Sources & evidence

ORD record
ord-75634c12b2d04692938e9e65df7cabcb
Source dataset
uspto-grants-2004_11
Patent number
US06822069B2

Reaction notes

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