7-(2-Chloro-4,6-dimethylphenyl)-2-methyl-3-(1-propyl but-1-enyl)-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-b]pyridine → 7-(2-chloro-4,6-dimethylphenyl)-2-methyl-3-(1-propylbutyl)-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-b]pyridine

HRID 2416107노트

반응식

HRID 2416107 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH3:9])[C:3]=1[N:10]1[CH2:15][CH2:14][CH2:13][C:12]2=[C:16]([C:20]([CH2:24][CH2:25][CH3:26])=[CH:21][CH2:22][CH3:23])[N:17]([CH3:19])[N:18]=[C:11]12>C(O)(=O)C.[Pd].C(OCC)(=O)C>[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH3:9])[C:3]=1[N:10]1[CH2:15][CH2:14][CH2:13][C:12]2=[C:16]([CH:20]([CH2:24][CH2:25][CH3:26])[CH2:21][CH2:22][CH3:23])[N:17]([CH3:19])[N:18]=[C:11]12

참가 물질

5

반응물 1

HCID 692923867-(2-Chloro-4,6-dimethylphenyl)-2-methyl-3-(1-propyl but-1-enyl)-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-b]pyridine

생성물 1

HCID 221362617-(2-chloro-4,6-dimethylphenyl)-2-methyl-3-(1-propylbutyl)-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-b]pyridine수율 24.4%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 176Acetic Acid용매HCID 8857Ethyl Acetate용매

실험 절차

7-(2-Chloro-4,6-dimethylphenyl)-2-methyl-3-(1-propylbut-1-enyl)-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-b]pyridine (41.5 mg) was dissolved in acetic acid (1 mL) and 12 mg of 10% palladium on carbon was added. The mixture was stirred under hydrogen at one atmosphere for 12 h. The mixture was diluted with ethyl acetate and filtered through diatomaceous earth which was then washed with ethyl acetate. The ethyl acetate filtrate was washed with aqueous sodium bicarbonate, dried with magnesium sulfate, and concentrated. The residue was chromatographed on silica gel eluting with an acetone/hexane gradient to provide 10.2 mg of 7-(2-chloro-4,6-dimethylphenyl)-2-methyl-3-(1-propylbutyl)-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-b]pyridine, as a crystalline film, ms m/z 374 (MH+).

후처리

  1. filtrationfiltered through diatomaceous earth which
  2. washwas then washed with ethyl acetate
  3. washThe ethyl acetate filtrate was washed with aqueous sodium bicarbonate
  4. dry with materialdried with magnesium sulfate
  5. concentrationconcentrated
  6. customThe residue was chromatographed on silica gel eluting with an acetone/hexane gradient

출처 및 근거

ORD 기록
ord-1c46476e947b4a0db3dcb82bf9e86b5f
출처 데이터셋
uspto-grants-2004_11
특허 번호
US06821984B2

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