Cytidine → N4-Acetylcytidine

Participants

Reaction Steps

To a solution of cytidine (1.22 g, 5.00 mmol) in DMF(40 mL) is added acetic anhydride (0.94 mL, 10.00 mmol). The solution is treated with microwave radiation (Panasonic, 1000 Watts) at full power for 40 seconds. The solution is concentrated in vacuo and the residue is co-evaporated with methanol (2×20 mL) to give 4-N-acetyl-cytidine (1.43 g, 95.0%) as a white powder. MS (FAB):m/z 286 (MH+).

Provenance & Evidence