1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 131724651, compound

Participants

Reaction Steps

A solution of 16.1 g of Z-DPhe-OH, 10 g of H-NMeVal-OMe hydrochloride and 10.1 ml of diisopropyl-ethylamine in 100 ml of dichloromethane is cooled to 0-5° and 11.35 g of EDCI are added. The mixture is first stirred-for one hour at 0-5°, then overnight at room temperature. The solvent is removed and the residue is taken up in MTBE and washed with Na2CO3 (5%), 1N HCl and water and dried. After removal of the solvent, Z-DPhe-NMeVal-OMe is obtained in a yield of 84.5%.

Provenance & Evidence