Water → HCID 178427564, compound

Participants

Reaction Steps

A solution of 30 g of Z-Arg(Pbf)-Gly-OtBu in 350 ml of THF is mixed with 3 g of water-moist Pd/C (10%) and the Z group is removed by hydrogenation under a gentle stream of H2. The catalyst is then filtered off and the solvent is removed. The residue is taken up in ethyl acetate and treated further as in Example 2.1. H-Arg(Pbf)-Gly-OtBu is obtained in a yield of 86%.

Provenance & Evidence