HCID 178418361, compound → HCID 178427501, compound

Participants

Reaction Steps

A solution of 2 g of cyclo(Arg(Pbf)-Gly-Asp(OBzl)-DPhe-NMeVal) in 26 ml of THF is mixed with 0.5 g of Pd/C (10%). Hydrogen is passed through for 2 hours, the mixture is freed of the catalyst and the solvent is removed in vacuo. The product crystallizes after addition of 32 ml of acetone, and is filtered off and dried. Cyclo(Arg(Pbf)-Gly-Asp-DPhe-NMeVal) is obtained in a yield of 83%.

Provenance & Evidence