HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylamine → 4-[2-(2-Hydroxyethyl)-1-benzofuran-5-yl]benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylamine | HCID 7912 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 3-Butyn-1-OL | HCID 13566 | — |
| Reactant | Phosphine | HCID 24404 | — |
| Reactant | 4-(4-Hydroxy-3-iodophenyl)benzonitrile | HCID 10358676 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Isopropyl Acetate | HCID 7915 | — |
| Product | 4-[2-(2-Hydroxyethyl)-1-benzofuran-5-yl]benzonitrile | HCID 11482439 | — |
Reaction Steps
treating 4′-hydroxy-3′-iodo-1,1′-biphenyl-4-carbonitrile with 3-butyn-1-ol, a palladium source with a phosphine for the palladium and a metal halide in the presence of a base, for example using palladium(ll) acetate, triphenylphosphine, copper(I) iodide in the presence of diisopropylamine, in isopropyl acetate to provide 4-[2-(2-hydroxyethyl)-1-benzofuran-5-yl]benzonitrile;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06822101B2 |
| Source dataset | uspto-grants-2004_11 |
| ORD ID | ord-a749ea9df7734388ae54dd2af57e057c |
| Source note | uspto-grants-2004_11 |