Ammonia → HCID 69539402, compound

Participants

Reaction Steps

To 1.0 g of 3′,5′-O-bis (4-chlorobenzoyl)-2′-deoxyuridine was added 5 mL of acetonitrile, 0.40 g of triethylamine, 0.24 g (1.2 times moles based on the uridine derivative) of 1-methylpiperidine and 0.76 g of p-toluenesulfonyl chloride, and the reaction mixture was stirred in an ice bath for 2 hours. To this, 7.5 mL of a solution of ammonia in 2-propanol was added, and the mixture was stirred in an ice bath for 4 hours, and at room temperature for 1 hour. The crystals were filtered and washed with acetonitrile to give 0.54 g of 3′,5′-O-bis(4-chlorobenzoyl)-2′-deoxycytidine. Yield 54%.

Provenance & Evidence