Uridine → HCID 69539402, compound

Participants

Reaction Steps

To 2.0 g of 3′,5′-O-bis(4-chlorobenzoyl)-2′-deoxyuridine was added 60 mL of acetonitrile, 0.81 g of triethylamine, 0.54 g (1.2 times moles based on the uridine derivative) of 1,4-diazabicyclo[2.2.2]octane and 1.5 g of p-toluenesulfonyl chloride, and the resulting mixture was stirred at room temperature for 3 hours. Ammonia gas was bubbled into the reaction mixture at room temperature for 1 hour, and the mixture was stirred in an ice bath for 30 minutes. The crystals were filtered and washed with acetonitrile to give 1.52 g of 3′,5′-O-bis(4-chlorobenzoyl)-2′-deoxycytidine. Yield 75.2%.

Provenance & Evidence