Chloroform → HCID 69539402, compound

Participants

Reaction Steps

To 3.0 g of 3′,5′-O-bis(4-chlorobenzoyl)-2′-deoxyuridine was added 30 mL of chloroform, 0.72 g of triethylamine, 0.80 g (1.2 times moles of uridine derivative) of 1,4-diazabicyclo[2.2.2]octane and 1.36g of p-toluenesulfonyl chloride, and the resulting mixture was stirred at room temperature for 30 minutes. Ammonia gas was bubbled into the reaction mixture at room temperature for 1 hour, and the mixture was stirred in an ice bath for 1 hour. After sludging by the addition of 100 mL of water and 100 mL of methanol, the crystals were filtered and washed with the mixed solution of water and methanol (1:1) to give 2.42 g of 3′,5′-O-bis(4-chlorobenzoyl)-2′-deoxycytidine. Yield 80.9%.

Provenance & Evidence