p-Toluenesulfonic acid → Ethanone, 1-(2,6,6-trimethyl-3-cyclohexen-1-yl)-

Participants

Reaction Steps

In a 500-ml four-necked flask equipped with a thermometer, a condenser and a stirrer, placed were 2,6,6-trimethyl-3-cyclohexenyl methyl ketone (10 g) synthesized in Referential Example 1, toluene (100 ml) and p-toluenesulfonic acid (2 g). Under stirring, they were reacted at 125° C. for 6 hours. The reaction mixture sampled at this time was analyzed by gas chromatography, resulting in that the content of trans-2,6,6-trimethyl-3-cyclohexenyl methyl ketone (1a′) was 17%, that of 2,6,6-trimethyl-2-cyclohexenyl methyl ketone (1b) was 56.5%, and that of 2,6,6-trimethyl-1-cyclohexenyl methyl ketone (1c) was 26.5%.

Provenance & Evidence