Methyl 4-chloroacetoacetate → HCID 22638652, compound

HRID 2416194Notes

Reaction equation

HRID 2416194 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([NH2:9])=[S:8])=[CH:5][N:4]=1.Cl[CH2:13][C:14](=O)[CH2:15][C:16]([O:18][CH3:19])=[O:17]>>[CH3:1][O:2][C:3]1[N:4]=[CH:5][C:6]([C:7]2[S:8][CH:13]=[C:14]([CH2:15][C:16]([O:18][CH3:19])=[O:17])[N:9]=2)=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 36240Methyl 4-chloroacetoacetateHCID 27459796-methoxypyridine-3-carbothioamide

Product 1

HCID 22638652HCID 22638652, compound

Procedure

This material was prepared according to the procedure described for Example 24(a) using 6-methoxythionicotinamide (Maybridge) (1.68 g, 10.0 mmol) and methyl 4-chloroacetoacetate (1.42 g, 10.0 mmol). Chromatography (gradient elution: 0-20% EtOAc in hexanes) of the crude material afforded the compound as an off-white solid. MS m/z: 265 (M+1). Calc'd for C12H12N2O3S: 264.06.

Workup

  1. customThis material was prepared
  2. washChromatography (gradient elution: 0-20% EtOAc in hexanes) of the crude material

Sources & evidence

ORD record
ord-75531a77d02a4ebdab18add0464786c0
Source dataset
uspto-grants-2004_11
Patent number
US06822097B1

Reaction notes

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